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DCN neuron adaptation is exceptionally slow and bidirectional. We perform current-clamp recordings at near physiological temperature in acute brain slices from mice of both sexes to examine how DCN neurons respond to prolonged depolarizations. Here we test whether DCN neurons undergo spike frequency adaptation that could account for these properties. Igor pro if statement Pc#However, prolonged reductions of PC inhibition, as seen in some disease states, certain types of transgenic mice, during optogenetic suppression of PC firing, and in acute slices of the cerebellum, do not lead to large, sustained increases in DCN firing. Brief reductions of PC firing rapidly increase DCN neuron firing. Development funded by Wavemetrics, Inc.Purkinje cells (PCs) are spontaneously active neurons of the cerebellar cortex that inhibit glutamatergic projection neurons within the deep cerebellar nuclei (DCN) that provide the primary cerebellar output.
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